Home General Physiology and Biophysics 2017 General Physiology and Biophysics Vol.36, No.4, p.471–479, 2017

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.36, No.4, p.471–479, 2017

Title: Evaluation of liposomal carnosine in adjuvant arthritis
Author: Lukáš Slovák, Silvester Poništ, Tatiana Fedorova, Anna Logvinenko, Irina Levacheva, Olga Samsonova, Udo Bakowsky, Ľudmila Pašková, Tomáš Čavojský, Lia Tsiklauri, Katarína Bauerová
Abstract: Liposomal carnosine could overcome the problems associated with direct application of this peptide. Anti-inflammatory and antioxidant effects of liposomal and non-liposomal carnosine in adjuvant arthritis were compared. The experiments were done on healthy animals, untreated arthritic animals, arthritic animals with oral administration of carnosine, and with subcutaneous administration of liposomal carnosine, both administered in the same daily dose of 150 mg/kg b.w. during 28 days. Carnosine reduced hind paw volume on day 28. Both forms markedly decreased interleukin-1β, matrix metalloproteinase-9 and monocyte chemoattractant protein-1 (MCP-1) in plasma on day 14. Only liposomal carnosine reduced significantly MCP-1. Malondialdehyde, 4-hydroxynonenal, resistance to Fe2+-induced oxidation and protein carbonyls were significantly corrected after administration of any form of carnosine. Liposomal carnosine corrected more effectively the oxidative stress in plasma than did carnosine. In brain tissue, our results showed protective ability of both forms of carnosine against oxidation of proteins and lipids. They also corrected the resistance to Fe2+-induced oxidation in arthritic animals. We found that only liposomal carnosine decreased the mRNA expression of inducible nitric oxide synthase in cartilage tissue. It can be concluded that the liposomal drug-delivery system is improving the pharmacological properties of carnosine administered in arthritis.
Keywords: Liposomes — Adjuvant arthritis — Oxidative stress — Carnosine — Inflammation
Published online: 13-Sep-2017
Year: 2017, Volume: 36, Issue: 4 Page From: 471, Page To: 479
doi:10.4149/gpb_2017014


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