General Physiology and Biophysics Vol.36, No.4, p.481

General Physiology and Biophysics Vol.36, No.4, p.481–484, 2017

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.36, No.4, p.481–484, 2017
Title: Effects of natural ligands and synthetic triorganotin compounds of nuclear retinoid X receptors in human MCF-7 breast cancer cell line
Author: Dana Macejova, Lucia Toporova, Julius Brtko

Abstract: In the present study, we analyzed in vitro effects of natural and synthetic triorganotin ligands of nuclear retinoid X receptors in human MCF-7 breast cancer cells. Our data has shown that all-trans retinoic acid significantly reduced expression of RXRalpha mRNA, Bcl2 and enhanced expression of BAX proteins. Tributyltin bromide markedly decreased mRNA level of RXRalpha and RXRbeta. Significantly reduced levels of both RXRs proteins were observed after treatment with tributyltin chloride (TBT-Cl) but not after treatment with triphenyltin chloride (TPT-Cl) for RXRbeta protein. Both RXRalpha and RXRbeta protein levels decrease was found also by combination ATRA+TBT-Cl/TPT-Cl.

Keywords: Triorgatonins – Retinoid X receptor – Human breast carcinoma cells
	Published online: 13-Sep-2017
Year: 2017, Volume: 36, Issue: 4	Page From: 481, Page To: 484
doi:10.4149/gpb_2017038
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