Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.9, p.517-522, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.118, No.9, p.517-522, 2017

Title: Analysis of HLA-G gene polymorphisms in Slovak women with pre-eclampsia
Author: V. Durmanova, J. Drobny, I. Shawkatova, J. Dlhopolcek, M. Bucova

Abstract:

OBJECTIVES: To identify possible association between the selected HLA-G gene polymorphisms and risk of pre-eclampsia.
BACKGROUND: Pre-eclampsia is a serious multisystem disorder that affects women during pregnancy. Despite many research studies, the pathology of pre-eclampsia is not fully understood. Human leukocyte antigen G (HLA-G) belongs to the molecules that induce fetal acceptance by the maternal immune system. HLA-G expression was found to be impaired in the women suffering from pre-eclampsia suggesting its involvement in the development of pre-eclampsia.
METHODS: 123 women with pre-eclampsia and 102 women with normotensive pregnancy were included in the study. HLA-G gene polymorphisms affecting its expression was determined, namely the HLA-G 14 bp insertion/deletion polymorphism in the 3’UTR and HLA-G 1597ΔC polymorphism tagging the HLA-G*01:05N null allele. Genotyping was performed by PCR and PCR-RFLP.
RESULTS: No statistically significant differences in either allele or genotype frequencies between pre-eclampsia cases and control group have been observed (p > 0.05).

CONCLUSION: Genetic predisposition of HLA-G to pre-eclampsia in Slovak women was examined for the first time. No association between analysed HLA-G gene polymorphisms and susceptibility to pre-eclampsia was observed. Further investigations are needed to determine the role of immunosuppressive molecule HLA-G in pre-eclampsia development (Tab. 5, Fig. 2, Ref. 37).



Keywords: HLA-G, pre-eclampsia, gene polymorphism, genotyping, diagnostic
Published online: 18-Oct-2017
Year: 2017, Volume: 118, Issue: 9 Page From: 517, Page To: 522
doi:10.4149/BLL_2017_100


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