Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.9, p.557-563, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.118, No.9, p.557-563, 2017

Title: Protective effect of ischemic preconditioning on testis injury following transient focal cerebral ischemia in diabetic rats
Author: M. Kumas, O. Altintas, M. Esrefoglu


OBJECTIVES: We aim to evaluate the effect of ischemic preconditioning (IPreC) on testicular tissue after transient middle cerebral artery occlusion (MCAo) in Streptozotocin-induced diabetic (STZ) and non-diabetic rats.
METHODS: Testis injury and alterations of testosterone levels were evaluated histologically.. Testicular damage was detected by using hematoxylin- eosin and periodic acid- schiff staining and apoptosis was identified by terminal-deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL).
RESULTS: Total mean serum testosterone levels decreased in all diabetic groups (p < 0.05) although remote ischemia and IPreC did not have any effect.

Serious testicular tubular damage was observed in both, diabetic and ischemic groups (p 0.05). Otherwise, remote IPreC induced MNAC instead of any changes in histopathological architecture. Moreover, remote IPreC reduced the tubular degeneration against synergistic damage of both ischemia and diabetes (p < 0.05).
CONCLUSIONS: It can be suggested that remote ischemic preconditioning prevents testicular damage by improving histopathological alterations and inducing apoptosis, probably temporarily, after focal transient middle cerebral artery occlusion in both, diabetic and non-diabetic rats. This is the first report demonstrating protective effects of ischemic preconditioning on remote testis injury after transient middle cerebral artery occlusion in diabetic rats (Fig. 6, Ref. 23).

Keywords: diabetes mellitus, experimental, cerebral infarction, experimental, ischemic preconditioning, testes, remote organ
Published online: 18-Oct-2017
Year: 2017, Volume: 118, Issue: 9 Page From: 557, Page To: 563

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