Home CONTACT Acta Virologica 2017 Acta Virologica Vol.61, No.4, p.487-491, 2017

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.61, No.4, p.487-491, 2017

Title: Calcium signaling involved in bovine herpesvirus 1 replication in MDBK cells
Author: L. ZHU, L. HUANG, Y. ZHU, X. DING, G. ZHU

Abstract: Calcium is one of the most prominent second messengers in eukaryotic cells. The involvement of calcium signaling in bovine herpesvirus 1 (BoHV-1) replication was not yet reported. In this study, we revealed that the L-type Ca2+ calcium channel blocker, Verapamil and store-operated calcium channel blocker, 2-aminoethyl diphenylborinate (2-APB) inhibited BoHV-1 replication in MDBK cells at the post-entry stages, and the Na+/Ca²+ exchanger inhibitor, N-arachidonoyl glycine exchanger (NAGly) interfered with the viral entry process. NAGly also effected the phosphorylation of PLCγ-1 at Ser1248, which corroborated our previous findings, that PLCγ-1 is important for BoHV-1 entry. Collectively, these results suggest that diverse calcium channels are employed by BoHV-1 for efficient replication.

Keywords: BoHV-1; calcium; calcium channel blocker
Published online: 17-Nov-2017
Year: 2017, Volume: 61, Issue: 4 Page From: 487, Page To: 491

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