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Bratislava Medical Journal Vol.118, No.10, p.580-584, 2017 |
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Title: Comparative analysis of human omental milky spots between the patients with colon cancer and the control group | ||
Author: L. Havrlentova, H. Faistova, M. Mazur, D. Ziak, S. Polak | ||
Abstract: AIM: Morphological description of milky spots (MSs) in the human greater omentum. METHOD: Samples of the greater omentum collected during surgical procedures were subjected to further histological analysis. Two groups of patients were studied. Group A consisted of patients with colon cancer and peritonitis (stimulated MSs), group B consisted of patients without colon cancer and without peritonitis (unstimulated MSs). In the research, we focused on the cellular composition and differences between stimulated and unstimulated MSs. RESULTS: MSs detected in the study were predominantly oval (67 %), round (12 %) or irregular in shape (21 %). The average number of immune cells found in one milky spot (MS) in the group A was 454 (209–694), consisted of T cells in 44.7 % (27–55 %), B cells in 26.8 % (16–34 %), macrophages in 18.3 % (12–27 %) and other immune cells in 10.2 % (6–18 %). The average number of immune cells found in one MS in the group B was 58 (42–100 %), consisted of T cells in 21.1 % (16–22 %), B cells in 18.7 % (13–22 %), macrophages in 46.9 % (33–60 %) and other immune cells in 13.3 % (1–22 %). The average size of MSs in the group A was significantly higher than in the group B: 768 μm (313–1075) to 293 μm (197–421). The results showed that there were significant differences in terms of strong predominance of macrophages in unstimulated milky spots and strong predominance of T cells in stimulated milky spots. CONCLUSION: MSs are specific immune active lymphatic structures on the greater omentum. They play a key role in defense mechanism, especially in peritonitis. Their function is not completely clear in cancer, some authors suggest they might play a significant role in omental metastasis. Further analysing of the morphology and cells interactions of MSs is needed (Tab. 2, Fig. 6, Ref. 20). |
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Keywords: milky spots, peritonitis, colon cancer, omentum | ||
Published online: 13-Nov-2017 | ||
Year: 2017, Volume: 118, Issue: 10 | Page From: 580, Page To: 584 | |
doi:10.4149/BLL_2017_111 |
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