Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.10, p.602-608, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.118, No.10, p.602-608, 2017

Title: Immunohistochemical investigation of P16, P53 and Ki-67’s prognostic values in diffuse large B-Cell lymphomas
Author: M. Baran, O. Canoz, H. Altuntas, S. Sivgin, M. Cetin, A. Yay, S. Ketenci


AIM: The aim of this study is to determine the immunohistochemical properties of Ki-67, P53 expression and loss of P16, and to assess their relationship with both clinical parameters and patient survival in DLBCL.
METHOD: Forty patients, diagnosed at the Pathology Department of our institute with nodal DLBCL were selected as the study group. The relationship between P16, P53, Ki-67 expressions and clinical and laboratory parameters like age, gender, performance status, Eastern Cooperative Oncology Group (ECOG), clinical stage, presence of B-symptoms, bone marrow involvement, International Prognostic Index (IPI) score, lactate dehydrogenase (LDH) level, extranodal extension, relapse, C-reactive protein (CRP), sedimentation, number of leukocytes in patients and patient survival were then statistically evaluated.
RESULTS: Our results display no statistically significant correlation between P53 expression and loss of P16, Ki-67 proliferation index and clinical parameters and overall survival (p > 0.05).

The only statistically significant relationship was between loss of P16 and stage (p 0.05).
CONCLUSION: According to the results of our study, the loss of P16, P53 gene expression and Ki-67 proliferation index have no effect on life expectancy of patients with DLBCL (Tab. 2, Fig. 2, Ref. 29).

Keywords: diffuse large B-cell lymphomas, P16, P53, Ki-67, prognosis
Published online: 13-Nov-2017
Year: 2017, Volume: 118, Issue: 10 Page From: 602, Page To: 608

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