Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.10, p.626-631, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.118, No.10, p.626-631, 2017

Title: Early detection of cardiac surgery‑associated acute kidney injury by microRNA-21
Author: P. Arvin, H. R. Samimagham, H. Montazerghaem, M. Khayatian, H. Mahboobi, F. Ghadiri Soufi


We tested the hypothesis whether microRNA-21 (miR-21) can detect CSA-AKI earlier than serum creatinine (sCr). A total of 103 patients scheduled to undergo cardiac surgery. CSA-AKI was defined as sCr > 0.3 mg/dl 24 h after surgery.

The patients were divided into two groups according to whether or not developing AKI after surgery. Serum and urinary miR-21 were measured prior to, and 6, 12 and 24 h after surgery.
Baseline serum and urinary levels of miR-21 in AKI group were lower than in non-AKI group. Moreover, the levels of miR-21 were significantly lower 6 h after surgery for serum, and 6 and 12 h after surgery for urine samples than those before surgery in AKI group. Area under the curve (AUC) of the receiver operating characteristic (ROC) values were 0.81 (95% CI: 0.65–0.97) for serum miR-21 (6 h after surgery), 0.90 (95% CI: 0.79–0.99) for urine (6 h after surgery), and 0.86 (95% CI: 0.71–0.98) for urine (12 h after surgery).
While both postoperative serum and urinary miR-21 levels can predict AKI development, urinary miR-21 especially 6 h after surgery is a more reliable marker than serum miR-21 for detection of established CSA-AKI (Tab. 1, Fig. 3, Ref. 43).

Keywords: cardiac surgery, acute kidney injury (AKI), miRNA-21
Published online: 13-Nov-2017
Year: 2017, Volume: 118, Issue: 10 Page From: 626, Page To: 631

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