General Physiology and Biophysics Vol.36, No.5, p.501

General Physiology and Biophysics Vol.36, No.5, p.501–511, 2017

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.36, No.5, p.501–511, 2017
Title: The role of statins as therapeutic agents in cancer
Author: Janka Sopková, Eva Vidomanová, Ján Strnádel, Henrieta Škovierová, Erika Halašová

Abstract: Statins are the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This enzyme catalyzes conversion of HMG-CoA to mevalonate, which are the intermediates in cholesterol biosynthetic pathway. Statins also play an important role in carcinogenesis, because they are able to affect the cancer cell metabolism. Their effect has been observed in several cellular processes, such as angiogenesis, metastasis, apoptosis and cell proliferation. However, these effects are highly dependent on type of cancer and individual statins vary in their antitumor potential. This review summarizes the recent epidemiological evidence and preclinical studies that showed effects of all clinically used statins in vitro and in vivo. We also consider the results of different observational and retrospective studies focused on association among statins and cancer risk which are still under open discussion.

Keywords: Statins — Cancer — Mevalonate pathway — Cholesterol
	Published online: 17-Nov-2017
Year: 2017, Volume: 36, Issue: 5	Page From: 501, Page To: 511
doi:10.4149/gpb_2017045
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