Home General Physiology and Biophysics 2017 General Physiology and Biophysics Vol.36, No.5, p.521–529, 2017

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.36, No.5, p.521–529, 2017

Title: DNA methylation as mechanism of apoptotic resistance development in endometrial cancer patients
Author: Veronika Fialkova, Eva Vidomanova, Tomas Balharek, Juraj Marcinek, Erik Kudela, Sandra Hanysova, Jozef Visnovsky, Dusan Dobrota, Jozef Hatok


DNA methylation is a significant epigenetic modification which plays a key role in regulation of gene expression and influences functional changes in endometrial tissue. Aberrant DNA methylation changes result in deregulation of important apoptotic proteins during endometrial carcinogenesis and apoptosis resistance development. Evading apoptosis is still a major problem in the successful treatment of endometrial cancer patients. The aim of our study was to examine the promoter DNA methylation changes in 22 apoptosis-associated genes in endometrioid endometrial cancer patients, precancerous lesions and healthy tissue from various normal menstrual cycle phases using a unique pre-designed methylation platform. We observed as the first a significant difference in promoter DNA methylation status in genes: BCL2L11 (p < 0.001), CIDEB (p < 0.03) and GADD45A (p < 0.05) during endometrial carcinogenesis and BIK gene (p < 0.03) in different phases of normal menstrual cycle.

The results of our study indicate that deregulation of mitochondrial apoptotic pathway can considerably contributes to the apoptosis resistance development and may be helpful in identifying of new potent biomarkers in endometrial cancer.

Keywords: DNA methylation — Apoptosis — Endometrial cancer — Menstrual cycle
Published online: 17-Nov-2017
Year: 2017, Volume: 36, Issue: 5 Page From: 521, Page To: 529

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