Home 
General Physiology and Biophysics 2017 General Physiology and Biophysics Vol.36, No.5, p.531–537, 2017
General Physiology and Biophysics 2017 General Physiology and Biophysics Vol.36, No.5, p.531–537, 2017
Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.36, No.5, p.531–537, 2017 |
||
| Title: Proton MR spectroscopic imaging of human glioblastomas at 1.5 Tesla | ||
| Author: Petra Hnilicová, Romana Richterová, Ema Kantorová, Michal Bittšanský, Eva Baranovičová, Dušan Dobrota | ||
| Abstract: In this study we evaluated clinical feasibility of proton magnetic resonance spectroscopy metabolite mapping (1H MRSI) by using 1.5 Tesla MR-scanner in 10 patients with high-grade glioblastoma. In vivo 1H MRSI performed with a relatively short scan time of 20 minutes enabled to obtain comprehensive information about metabolic changes in glioblastoma and adjacent tissues namely in the peritumoral edema, in the middle and solid part of the tumor, and in the normal-appearing brain tissue. Spectroscopically it was possible to identify initiation of neuronal cell death in the solid tumorous tissue via decreased N-acetyl-aspartate to creatine ratio (↓ tNAA/tCr) and expanding carcinogenesis reflected in elevated choline ratios (↑ tCho/tCr and tCho/tNAA). We showed also the central necrosis of glioblastoma accompanied by the tissue hypoxia, which were apparent as increased lactate and lipids ratios (↑ Lac/tCr and lip/Lac). Metabolic changes were noticeable also in the peritumoral area, showing the glioblastoma infiltration into the surrounding tissues. In intracranial tumors, 1H MRSI performed on 1.5 Tesla field strength was sufficient to provide information about the stage of carcinogenesis, tumor expansion or necrotization and thus it could be considered as a useful diagnostic tool in oncology. |
||
| Keywords: 1H MRS — Brain — Glioblastoma — Carcinogenesis | ||
| Published online: 17-Nov-2017 | ||
| Year: 2017, Volume: 36, Issue: 5 | Page From: 531, Page To: 537 | |
| doi:10.4149/gpb_2017027 |
||
|
|
 download file |
|