Home General Physiology and Biophysics 2017 General Physiology and Biophysics Vol.36, No.5, p.549–556, 2017

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.36, No.5, p.549–556, 2017

Title: Testosterone as a prospective predictor of pathological Gleason score and pathological stage in prostate cancer
Author: Henrieta Drobková, Jana Jurečeková, Marián Grendár, Ján Kliment Jr., Erika Halašová, Ján Kliment
Abstract: The aim of the study was to assess the relationship between preoperative circulating levels of total serum testosterone and pathological Gleason score and pathological stage in prostate cancer patients who underwent radical retropubic prostatectomy. The levels of total serum testosterone were measured in the morning just before surgery in a group of 201 prostate cancer patients. Multinomial logistic regression models were used to model the association between total preoperative testosterone (individually or in combination with other preoperative predictors such as age, PSA, clinical stage and biopsy Gleason score) and pathological Gleason score, pathological stage in prostate cancer patients. The association between age and total testosterone was modelled by robust regression. The total serum testosterone, in combination with other prognostic factors (age, PSA, clinical stage and biopsy Gleason score) in models, was not statistically significant predictor of pathological Gleason score and pathological stage. The highly significant relationship between age and preoperative total testosterone was observed (p = 0). In prostate cancer patients, the level of total serum testosterone increased with age. In conclusion, total testosterone is not a statistically significant predictive factor for pathological Gleason score and pathological stage.
Keywords: Prostate cancer — Total serum testosterone — Pathological Gleason score — Pathological stage — Age
Published online: 17-Nov-2017
Year: 2017, Volume: 36, Issue: 5 Page From: 549, Page To: 556
doi:10.4149/gpb_2017044


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