Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.11, p.658-661, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.118, No.11, p.658-661, 2017

Title: Alpha-2-macroglobulin and hyaluronic acid as fibromarkers in patients with chronic hepatitis C
Author: B. Pitekova, V. Kupcova, E. Uhlikova, V. Mojto, L. Turecky

Abstract: BACKGROUND: Liver fibrosis is the final common pathway of chronic liver diseases of various etiology. From the practical standpoint, it would be ideal to have a noninvasive fibromarker. The aim of our study was to investigate the levels of alpha-2-macroglobulin, potential fibromarker, in correlation to histological staging and another potential fibromarker, hyaluronic acid, in patients with chronic hepatitis C.
METHODS: Population groups in this study consisted of 51 healthy volunteers and 54 patients with chronic hepatitis C. Liver biopsies were obtained under ultrasound guidance. Alpha-2-macroglobulin was determined by electroimmunodiffusion and hyaluronic acid with enzyme-linked binding protein assay.
RESULTS: Both potential fibromarkers, alpha-2-macroglobulin and hyaluronic acid, were increased in patients with chronic hepatitis C. The alpha-2-macroglobulin levels were not significantly increased in the groups F0–F1. In the groups F2–F4, alpha-2-macroglobulin levels were significantly higher than in the control group. The changes of hyaluronic acid were similar to changes of alpha-2-macroglobulin. Regression analysis showed a significant correlation between hyaluronic acid and alpha-2-macroglobulin levels.
CONCLUSIONS: According to the results of our study, it can be concluded that alpha-2-macroglobulin and hyaluronic acid might be useful markers of liver fibrosis (Tab. 2, Ref. 15).

Keywords: chronic hepatitis C, fibromarkers, liver fibrosis, alpha-2-macroglobulin, hyaluronic acid
Published online: 05-Dec-2017
Year: 2017, Volume: 118, Issue: 11 Page From: 658, Page To: 661

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