Home Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.12, p.740-745, 2017

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.118, No.12, p.740-745, 2017

Title: Periodontitis aggravates kidney damage in obese mice by MMP2 regulation
Author: P. Chen, D. Y. Xuan, J. C. Zhang

Abstract: OBJECTIVE:  To investigate the effect of periodontitis on the development of kidney damage in obese mice and its possible mechanism.
METHODS:  C57 BL/6J mice were fed high‑fat (HF) or low‑fat (LF) diet and then divided into four groups:  obesity with periodontitis (HFP), obesity without periodontitis (HFC), normal mice with periodontitis (LFP) and normal mice without periodontitis (LFC). Serum indicators of renal function, namely serum total protein (TP), albumin (ALB), creatinine (Cr) and blood urea nitrogen (UREA) were measured. The histopathological examination of kidney tissues was performed. The expressions of transforming growth factor-β1 (TGF-β1), matrix metalloproteinase-2 (MMP2) and tissue inhibitors of metalloproteinases-1 (TIMP1) were detected by immunohistochemistry and real time RT-PCR.
RESULTS:  Obesity decreased TP and ALB, and increased serum Cr and UREA levels in normal and periodontitis mice groups, as well as induced glomerular and tubulointerstitial pathologic changes. Tubulointerstitial fibrosis was more severe in HFP group. In obese mice, periodontitis caused the downregulation of MMP2, and upregulation of TIMP1 and TGF-β1 at transcriptional and translational levels.
CONCLUSIONS:  In obese mice, periodontitis may aggravate pathological changes in the kidney. The possible mechanism might lie in downregulation of MMP2 and upregulation of MMP inhibitor, TIMP1, and TGF-β1 (Tab. 1, Fig. 4, Ref. 16).

Keywords: obesity, periodontitis, kidney disease, MMP2
Published online: 04-Jan-2018
Year: 2017, Volume: 118, Issue: 12 Page From: 740, Page To: 745
doi:10.4149/BLL_2017_140


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