Home Neoplasma 2018 Neoplasma Vol.65, No.1, p.49-54, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.1, p.49-54, 2018

Title: MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression
Author: T.B. HU, H.S. CHEN, M.Q. CAO, F.D. GUO, X.Y. CHENG, Z.B. HAN, M.Q. LI

Abstract: Breast cancer is one of the most prevalent and fatal diseases around the world. The mechanism of tumorigenesis in breast cancer remains to be clarified. miR-421 plays an oncogenic role in many cancers. Although, the clinical significance of miR-421 in patients with breast cancer is still to be investigated. Caspase-10 is one of the initiator of apoptosis. But the relationship between miR-421 and caspase-10 has not been investigated. In the present study, we found that miR-421 was expressed much higher in breast cancer tissues compared to those in adjacent non-tumor tissues. Furthermore, miR-421 promotes cell proliferation and colony formation in vitro. miR-421 inhibits cell apoptosis probably through restraining caspase-10 expression. Thus, miR-421 might be a potential diagnostic maker and therapeutic target for breast cancer.

Keywords: miRNA-421, caspase-10, apoptosis, breast cancer
Published online: 11-Jan-2018
Year: 2018, Volume: 65, Issue: 1 Page From: 49, Page To: 54
doi:10.4149/neo_2018_170306N159
Price: 14.40 €






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