Home CUSTOMERS Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.1, p.3-5, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.119, No.1, p.3-5, 2018

Title: Late relapse in stage I of nonseminomatous germ cell testicular cancer on surveillance
Author: M. Ondrusova, M. Suchansky, M. Psota, T. Zeleny, D. Ondrus


OBJECTIVE: Primary aim was to assess relapse‑free survival (RFS) in patients with clinical stage I (CS I) of non-seminomatous germ cell testicular tumors (NSGCTT) undergoing surveillance after orchiectomy. The secondary aim was to examine differences in risk factors in patients with early relapse (ER 2 years) and very late relapse (VLR > 5 years).

METHODS: Cross-sectional study analyzed 25‑year single‑center experiences with 198 CS I NSGCTT patients according the time to relapse.
RESULTS: RFS was 160/198 (80.8 %). Relapse occurred in 38 (19.2 %) patients after a median fol­low-up of 7.57 months, 33 (86.8 %) patients had ER after a median follow-up of 7.03 months and 5 patients had LR (13.2 %) after a median follow-up of 26.28 months. One patient (2.63 %) had VLR after follow-up > 5 years (7.17 years). Three relapsed patients died with metastatic disease after a mean follow-up of 5.1 years from the date of diagnosis. Another three patients died without cancer after a mean follow-up of two years. OS was 192/198 (97 %).
CONCLUSION: Diagnosis and treatment of late relapsing NSGCTT patients should be performed in experienced centers only. Occurrence of LR is the reason for long-term monitoring of NSGCTT survivors (Tab. 1, Fig. 1, Ref. 14).

Keywords: testicular cancer, active surveillance, clinical stage, late relapse
Published online: 22-Jan-2018
Year: 2018, Volume: 119, Issue: 1 Page From: 3, Page To: 5

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