Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.1, p.32-35, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.119, No.1, p.32-35, 2018

Title: Both experimental hypothyroidism and hyperthyroidism increase cardiac irisin levels in rats
Author: E. Atici, E. Menevse, A. K. Baltaci, R. Mogulkoc

Abstract: Irisin is a newly discovered myokine and adipokine that increases total body energy expenditure. The aim of this study was to determine the effect of experimental hypothyroidism and hyperthyroidism on the levels of irisin in heart tissue in rats. The study was performed on the 40 male Sprague–Dawley rats. Experimental groups were designed as; Control, Hypothyroidism, Hypothyroidism+L-Thyroxine, Hyperthyroidism and Hyperthyroidism + PTU. Following 3 weeks experimental period, irisin levels were determined in heart tissues. Hypothyroidism group values of irisin were higher than in the control group, but lower than in the hyperthyroidism group. The hyperthyroidism group had the highest levels of cardiac irisin. The results of the study showed that the experimental hypothyroidism and hyperthyroidism increased the heart irisin levels, but the increase in the hyperthyroidism group was much higher than in the hypothyroidism group. However, treatment of hypothyroidism and hyperthyroidism corrected cardiac irisin levels (Fig. 1, Ref. 28).

Keywords: hyperthyroidism, hypothyroidism, heart tissue, irisin, rat
Published online: 22-Jan-2018
Year: 2018, Volume: 119, Issue: 1 Page From: 32, Page To: 35

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