Acta Virologica Vol.62, No.1, p.28-32, 2018

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.62, No.1, p.28-32, 2018
Title: Highlighting the 'blood-nerve barrier' in virology research
Author: I. Mori

Abstract: The blood-nerve barrier (BNB) shields peripheral nerves from the blood in order to maintain the homeostasis of the nervous system. In the field of infectious diseases, little information is currently available concerning the BNB. Recently documented evidence in virology suggests that elevated permeability of the BNB by immune cells and the natural absence of the BNB in the olfactory mucosa play significant roles in neuroprotection as well as neuropathogenesis. Importantly, the BNB can behave more flexibly than previously thought. In the near future, drug delivery via manipulation of the BNB will shed light on new therapeutic and prophylactic strategies for serious and intractable nervous system infections.

Keywords: blood-nerve barrier; virus; viremia; antibody; interferon-γ; olfactory nerve
	Published online: 09-Mar-2018
Year: 2018, Volume: 62, Issue: 1	Page From: 28, Page To: 32
doi:10.4149/av_2018_103
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