Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.1, p.33–40, 2018

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.37, No.1, p.33–40, 2018

Title: The contribution of noradrenergic nerves to the vasoconstrictor response during local cooling of leg and forearm skin in humans
Author: Ramzi A. Al-horani, Mukhallad Mohammad


This study investigated the noradrenergic contribution during the cutaneous vasoconstrictor response to local cooling in the leg and forearm. On each limb, one site was perfused with Yoh/Prop to block the postsynaptic adrenoceptors and another with Lactated Ringer’s (control) using microdialysis. Blood flow was measured by Laser-Doppler flowmetry (LDF). Cutaneous vascular conductance (CVC) was calculated as LDF units divided by the mean arterial pressure. After baseline measures, skin was locally cooled to 24°C. Basal CVC was similar at all sites in the leg and forearm (all p > 0.1).

During the first 10 min of local cooling, CVC was reduced in the leg (p < 0.005) and unchanged in the forearm control sites (p = 0.2). Yoh/Prop induced an increased CVC in the leg and forearm to a similar level (39.2 ± 11.5, and 41.3 ± 3.3%CVC, respectively; p < 0.35). Late during local cooling, the vasoconstriction was attenuated in the leg and forearm at Yoh/Prop (–38.2 ± 5.3 –37.1 ± 5.3%CVC, respectively; p = 0.5) compared to control sites (–69.1 ± 5.8 vs. –54.5 ± 6.4%CVC, respectively; p < 0.005). Noradrenergic contribution was greater in the leg than the forearm during the late vasoconstrictor response (p = 0.006). These data indicate that the leg skin can induce greater vasoconstriction than forearm during local cooling, possibly via higher noradrenergic sensitivity in the leg skin.

Keywords: Local cooling — Noradrenergic activity — Vasoconstrictor response — Skin blood flow — Autonomic — Cutaneous vascular conductance
Published online: 22-Jan-2018
Year: 2018, Volume: 37, Issue: 1 Page From: 33, Page To: 40

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