Home 
General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.1, p.111–120, 2018
General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.1, p.111–120, 2018
Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.37, No.1, p.111–120, 2018 |
||
| Title: Water-soluble quercetin modulates the choleresis and bile lipid ratio in rats | ||
| Author: Tetyana Vovkun, Petro Yanchuk, Lidiya Shtanova, Stanislav Veselskiy, Natalia Filimonova, Anatoly Shalamay, Volodymyr Vedmid | ||
| Abstract: Water-soluble analogue of quercetin, corvitin is used in patients with myocardial infarction as blocker of 5-lipoxygenase. However, its effects on secretion, lipid content and physico-chemical properties of bile have not been understood yet. We investigated the effect of corvitin, applied in different doses, on the level of bile flow, the content of bile free and esterified cholesterol, phospholipids, triacylglycerols, and free fatty acids. In order to determine stability of the bile colloidal system, we examined the relationship between different lipid components. The rats were injected intraportally with a bolus of corvitin. At doses of 2.5, 5, and 10 mg/kg, the latter increased bile flow and concentration of total cholates, as well as free fatty acids. Corvitin (5 mg/kg) elevated phospholipids and cholesterol content, but at a dose of 10 mg/kg it increased the concentration of bile cholesterol esters and triacylglycerols. Corvitin applied at doses of 2.5 and 10 mg/kg increased total cholates/cholesterol ratio, but at a dose of 10 mg/kg, the drug reduced cholesterol / esterified cholesterol ratio. The results suggest that corvitin exerts choleretic effect and improves stability of bile colloidal system. |
||
| Keywords: Water-soluble quercetin — Bile secretion — Bile lipid — Total bile acid — Lipid ratio | ||
| Published online: 22-Jan-2018 | ||
| Year: 2018, Volume: 37, Issue: 1 | Page From: 111, Page To: 120 | |
| doi:10.4149/gpb_2017015 |
||
|
|
 download file |
|