Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.1, p.111–120, 2018

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.37, No.1, p.111–120, 2018

Title: Water-soluble quercetin modulates the choleresis and bile lipid ratio in rats
Author: Tetyana Vovkun, Petro Yanchuk, Lidiya Shtanova, Stanislav Veselskiy, Natalia Filimonova, Anatoly Shalamay, Volodymyr Vedmid

Abstract: Water-soluble analogue of quercetin, corvitin is used in patients with myocardial infarction as blocker of 5-lipoxygenase. However, its effects on secretion, lipid content and physico-chemical properties of bile have not been understood yet. We investigated the effect of corvitin, applied in different doses, on the level of bile flow, the content of bile free and esterified cholesterol, phospholipids, triacylglycerols, and free fatty acids. In order to determine stability of the bile colloidal system, we examined the relationship between different lipid components. The rats were injected intraportally with a bolus of corvitin. At doses of 2.5, 5, and 10 mg/kg, the latter increased bile flow and concentration of total cholates, as well as free fatty acids. Corvitin (5 mg/kg) elevated phospholipids and cholesterol content, but at a dose of 10 mg/kg it increased the concentration of bile cholesterol esters and triacylglycerols. Corvitin applied at doses of 2.5 and 10 mg/kg increased total cholates/cholesterol ratio, but at a dose of 10 mg/kg, the drug reduced cholesterol / esterified cholesterol ratio. The results suggest that corvitin exerts choleretic effect and improves stability of bile colloidal system.

Keywords: Water-soluble quercetin — Bile secretion — Bile lipid — Total bile acid — Lipid ratio
Published online: 22-Jan-2018
Year: 2018, Volume: 37, Issue: 1 Page From: 111, Page To: 120

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