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Acta Virologica 2018 Acta Virologica Vol.62, No.1, p.78-85, 2018
Acta Virologica 2018 Acta Virologica Vol.62, No.1, p.78-85, 2018
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Acta Virologica Vol.62, No.1, p.78-85, 2018 |
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| Title: Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways | ||
| Author: R.-K. SEONG, J.-A. KIM, O. S. SHIN | ||
| Abstract: Wogonin, a flavonoid isolated from Scutellaria baicalensis, has attracted increasing scientific attention in recent years because of its potent anti-tumor activity. Its role during viral infection has largely been unexplored. Wogonin treatment effectively suppressed both influenza A and B virus replication in Madin-Darby Canine Kidney (MDCK) cells and human lung epithelial (A549) cells. In contrast, wogonin treatment following influenza A virus infection led to up-regulation of interferon (IFN)-induced antiviral signaling. Additionally, influenza A virus infection in A549 cells induced 5' adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and activation in a time-dependent manner and wogonin treatment led to the suppression of AMPK phosphorylation. Furthermore, the treatment with AMPK-specific inhibitor (compound C; CC) attenuated influenza A virus replication. These data suggest that wogonin possesses a potent anti-influenza activity mediated by regulation of AMPK activation, suggesting that wogonin has the potential to be developed as an anti-influenza drug. |
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| Keywords: wogonin; influenza; interferon; AMPK; anti-viral signaling | ||
| Published online: 09-Mar-2018 | ||
| Year: 2018, Volume: 62, Issue: 1 | Page From: 78, Page To: 85 | |
| doi:10.4149/av_2018_109 |
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