Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.3, p.160-166, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.5

 

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Bratislava Medical Journal Vol.119, No.3, p.160-166, 2018

Title: Astaxanthin effectiveness in preventing multiple sclerosis in animal model
Author: S. Bidaran, A. R. Ahmadi, P. Yaghmaei, M. H. Sanati, A. Ebrahim-Habibi
Abstract: OBJECTIVE: The aim of the present study was to reveal the effect of therapeutic and prophylactic potential of astaxanthin in experimental autoimmune encephalomyelitis (EAE) as an acceptable model for the study of multiple sclerosis (MS).
BACKGROUND: Astaxanthin has powerful antioxidant activities as well as several essential biological functions while multiple sclerosis prevention is highly regarded by researchers.
METHODS: The astaxanthin potential in prevention of multiple sclerosis was examined in the chronic model of experimental autoimmune encephalomyelitis (EAE) by using female C57BL/6 mice induced with oligodendrocyte glycoprotein (MOG). Splenocytes were assessed to measure the levels of proinflammatory and anti-inflammatory cytokines, proliferation rate and FoxP3+Treg cell frequency. Immunohistochemical examinations were performed on spinal cord and brain tissue.
RESULTS: Astaxanthin reduced splenocytes proliferation index and proinflammatory cytokine levels, and vice versa increased the anti-inflammatory cytokine levels. Immunohistochemical studies of the spinal cord and brain showed that the infiltration with inflammatory cells was highly confined in the central nervous system. Protective effects of astaxanthin were visible by assigning low score recording in clinical behavior and disease severity.
CONCLUSION: Astaxanthin is a powerful tool for intervention in EAE on a model of multiple sclerosis, so it can be studied further to prevent and treat MS (Tab. 2, Fig. 3, Ref. 41).
Keywords: astaxanthin, experimental autoimmune encephalomyelitis, female C57BL/6 mice, Haematococcus pluvialis, multiple sclerosis
Published online: 06-Mar-2018
Year: 2018, Volume: 119, Issue: 3 Page From: 160, Page To: 166
doi:10.4149/BLL_2018_031


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