Home FOR AUTHORS Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.3, p.180-186, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.119, No.3, p.180-186, 2018

Title: Preoperative platelet-to-lymphocyte ratio is a predictor of prognosis in patients with ampullary carcinoma
Author: N. S. Demirci, N. Y. Ozdemir, G. U. Erdem, Y. Bozkaya, O. Yazici, N. Zengin
Abstract: AIM: To emphasize the significance of the platelet-to-lymphocyte ratio (PLR) in estimating the postoperative prognosis or survival measures in patients with carcinoma of the ampulla of Vater.
METHODS: We retrospectively reviewed 82 patients, who underwent pancreaticoduodenectomy for ampullary carcinoma between July 2001 and April 2014. We investigated the predictive significance of the preoperative PLR for disease-free survival (DFS) or overall survival (OS). The possible correlations between the PLR and clinical or pathological features were also evaluated.
RESULTS: The 5-year DFS and OS rates of the patients with carcinoma of the ampulla of Vater after pancreaticoduodenectomy were 51 % and 64 %, respectively. Multivariate analysis revealed a significantly worse OS in patients with a PLR ≥ 212 [hazard ratio (HR): 3.446; 95% confidence interval (CI): 1.4–8.43; p = 0.007], lymphovascular invasion (HR: 2.973; 95% CI: 1.25–7.03; p = 0.013), or pathological stage pT3/4 (HR: 2.761; 95% CI: 1–7.1; p = 0.035). Similarly, DFS was significantly worse in patients with lymphovascular invasion (HR: 2.24; 95% CI: 1.1–4.56; p = 0.025) or stage pT3/4 (HR: 2.243; 95% CI, 1.03–4.84; p = 0.04).
CONCLUSION: The preoperative PLR shows a predictive significance for the prognosis of postoperative patients with carcinoma of the ampulla of Vater. We suggest that because of its predictive value, the PLR can be used in the development of further approaches to monitor and manage patients with poor prognosis Tab. 4, Fig. 1, Ref. 45).
Keywords: reoperative platelet-to-lymphocyte ratio, predictor of prognosis, ampullary carcinoma
Published online: 06-Mar-2018
Year: 2018, Volume: 119, Issue: 3 Page From: 180, Page To: 186
doi:10.4149/BLL_2018_033


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