Home Neoplasma 2018 Neoplasma Vol.65, No.2, p.178-184, 2018

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.65, No.2, p.178-184, 2018

Title: The association between LncRNA HOTAIR and cancer lymph node metastasis and distant metastasis: a meta-analysis
Author: Z. SUN, X. Y. WU, C. L. WU

Abstract:

HOTAIR has been reported to be associated with development and metastasis in different types of cancer. This meta- analysis collected all relevant articles and explored the correlation of HOTAIR with lymph node metastasis (LNM) and distant metastasis (DM). A literature collection was conducted by searching PubMed, Web of Science, Google Scholar and Cochrane Library (up to Sep 11, 2016). The odds ratio (OR) with 95% confidence interval (95% CI) was calculated to assess the association with strength. Nineteen studies were included in this study, with a total of 1874 patients. The study objects were all Asians. We found high HOTAIR expression in tumor tissues was significantly correlated with LNM and DM, and analysis showed a pooled OR of 3.18 (95% CI: 2.10–4.81, p<0.00001) and 3.93 (95% CI: 2.39–6.47, p<0.00001), respectively.

HOTAIR may serve as a novel diagnostic biomarker for cancer metastasis.



Keywords: HOTAIR, lymph node metastasis, distant metastasis, meta-analysis
Published online: 13-Mar-2018
Year: 2018, Volume: 65, Issue: 2 Page From: 178, Page To: 184
doi:10.4149/neo_2018_170114N34
Price: 16.80 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.