Home CUSTOMERS Neoplasma 2018 Neoplasma Vol.65, No.2, p.178-184, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.2, p.178-184, 2018

Title: The association between LncRNA HOTAIR and cancer lymph node metastasis and distant metastasis: a meta-analysis
Author: Z. SUN, X. Y. WU, C. L. WU


HOTAIR has been reported to be associated with development and metastasis in different types of cancer. This meta- analysis collected all relevant articles and explored the correlation of HOTAIR with lymph node metastasis (LNM) and distant metastasis (DM). A literature collection was conducted by searching PubMed, Web of Science, Google Scholar and Cochrane Library (up to Sep 11, 2016). The odds ratio (OR) with 95% confidence interval (95% CI) was calculated to assess the association with strength. Nineteen studies were included in this study, with a total of 1874 patients. The study objects were all Asians. We found high HOTAIR expression in tumor tissues was significantly correlated with LNM and DM, and analysis showed a pooled OR of 3.18 (95% CI: 2.10–4.81, p<0.00001) and 3.93 (95% CI: 2.39–6.47, p<0.00001), respectively.

HOTAIR may serve as a novel diagnostic biomarker for cancer metastasis.

Keywords: HOTAIR, lymph node metastasis, distant metastasis, meta-analysis
Published online: 13-Mar-2018
Year: 2018, Volume: 65, Issue: 2 Page From: 178, Page To: 184

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