Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Neoplasma Vol.65, No.2, p.287-291, 2018 |
||
Title: Clinically node-positive bladder cancer: oncological results of induction chemotherapy and consolidative surgery | ||
Author: M. STANIK, A. POPRACH, D. MACIK, I. CAPAK, D. MALUSKOVA, N. MARECKOVA, R. LAKOMY, J. JARKOVSKY, J. DOLEZEL | ||
Abstract: Patients with clinically node-positive bladder cancer have a poor prognosis, with many receiving only palliative chemo- therapy. We evaluated oncological results in bladder cancer patients with clinically regional and supraregional lymph- adenopathy treated with induction chemotherapy (IC) and consolidative cystectomy. Twenty-five patients with clinically node-positive bladder cancer (including pelvic and retroperitoneal nodes) were treated with 2–4 cycles of IC followed by consolidative cystectomy between 2010 and 2016. Pathologic complete response (pCR) was defined as no residual tumor in the final specimen (ypT0N0). pCR was seen in 7 (28%) patients; 50% in cN1 versus 13% in cN3-M1. pCR associated with 3-year CSS of 80% versus 45% in patients with persistent disease after IC. In conclusion, a multimodal approach to patients with clinically node-positive bladder cancer, consisting of IC followed by consolidative surgery, may achieve long-term survival in selected patients. Better results may be expected in patients with initially minimal nodal burden and complete pathologic response to chemotherapy. Further studies are warranted to improve patient selection for consolidative surgery, especially with supra-regional metastases. |
||
Keywords: urinary bladder neoplasms, lymphadenopathy, combined modality therapy, induction chemotherapy, cystectomy | ||
Published online: 13-Mar-2018 | ||
Year: 2018, Volume: 65, Issue: 2 | Page From: 287, Page To: 291 | |
doi:10.4149/neo_2018_170403N239 |
||
|
download file |
|