Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.2, p.175–184, 2018

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.37, No.2, p.175–184, 2018

Title: Toxicogenomic evaluation of liver responses induced by acrylamide and glycidamide in male mouse liver
Author: Dongyan Chen, Huangyou Liu, Enting Wang, Haiyang Yan, Haiqing Ye, Yuan Yuan

Abstract: In current studies, histopathologic method, Agilent GeneChip hybridization and Western blot were used to investigate the toxicity of acrylamide (AA) and glycidamide (GA) in male mouse livers. The histopathologic results demonstrated that AA and GA could cause oxidative damage to mouse liver. Middle dose of GA and AA (50 mg/kg b.w./day) could significantly up-regulate the expression of cytochrome P450, as well as genes related to oxidative injury, cancer and inflammation, and significantly down-regulate the expression of genes related to anti-apoptosis, anti-oncogene and fatty acid synthesis. Middle and high dose (75 mg/kg b.w./day) of GA and AA could both down-regulate the expression of hepatic anti-oncogene Bcl2 and up-regulate the expression of cancer-related gene Rad51 and EGFR protein. The expression of anti-oncogene P21 induced by AA and GA was decreased. Our current study demonstrated that the oxidative damage, immune injury and carcinogenicity of mouse liver samples could be induced by AA and GA at histopathological, entire genome and protein levels.

Keywords: Aacrylamide — Glycidamide — Gene expression profile — Oxidative damage — Carcinogenesis
Published online: 27-Mar-2018
Year: 2018, Volume: 37, Issue: 2 Page From: 175, Page To: 184

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