Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.2, p.193–204, 2018

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.37, No.2, p.193–204, 2018

Title: Upregulation of heme oxygenase 1 (HO-1) attenuates kidney damage, oxidative stress and inflammatory reaction during renal ischemia/reperfusion injury
Author: Mai Barakat, Mahmoud M. Gabr, Faten Zhran, Mohamed El-Adl, Abdelaziz M. Hussein, Nashwa Barakat, Reda Eldemerdash

Abstract:

The current study investigated the effect of upregulation of heme oxygenase 1 (HO-1) by cobalt protoporphyrin (CoPP) on renal dysfunctions in renal ischemia/reperfusion (I/R) injury and its underlying mechanisms. 72 male Sprague Dawley rats were divided into 4 groups: sham group, ischemic group (left 45-min renal ischemia), CoPP-before group (as ischemic group with CoPP 20 mg/kg 30 min before ischemia) and CoPP-after group (as ischemic group with CoPP 20 mg/kg 20 min after ischemia). Serum creatinine, urea and TGF-β1 and markers of redox state (MDA, SOD, GSH and CAT), nitric oxide (NO), TGF-β1 and HO-1 in kidney tissues were measured. Serum creatinine and urea levels were significantly increased in ischemic group and attenuated in CoPP-treated groups (p < 0.05).

Also, markers of redox state showed significant deteriorations in ischemic group which were improved significantly in CoPP-treated groups (p < 0.05). HO-1 expression in kidney tissues showed significant increase in ischemic group and showed more significant increase in CoPP-treated groups (p < 0.05). Moreover, serum and renal TGF-β1 levels were significantly increased in ischemic group and attenuated in CoPP-treated groups (p < 0.05). We concluded that up-regulation of HO-1 by CoPP treatment before and after renal I/R injury improved the kidney function and morphology and this might be due to impairment of oxidative stress and inflammatory cytokines in kidney tissues.



Keywords: Renal ischemia — TGF-β1 — Heme oxygenase 1 — Oxidative stress
Published online: 27-Mar-2018
Year: 2018, Volume: 37, Issue: 2 Page From: 193, Page To: 204
doi:10.4149/gpb_2017018
Price: 24.00 €






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