Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.4, p.198-200, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.119, No.4, p.198-200, 2018

Title: Canakinumab as monotherapy for treatment of familial Mediterranean fever – first report in Central and Eastern Europe region
Author: M. Jesenak, K. Hrubiskova, L. Kapustova, M. Kostkova, P. Banovcin

Abstract: Autoinflammatory disorders (AID) are characterized by spontaneous attacks of acute inflammation with a broad spectrum of clinical symptoms. Ongoing inflammation and reoccurrence of acute flares can lead to the development of amyloidosis. One group of AID is represented by monogenic periodic fever syndromes while familial Mediterranean fever (FMF) is the most common form of AID from this group. Its prevalence in Central and Eastern Europe was reported to be very low. We report a case of FMF patient with a very severe clinical course of FMF and intolerance to colchicine, which is a gold standard for FMF treatment. The clinical effect of the application of anakinra was insufficient and accompanied with side effects and low tolerability. Switching to canakinumab (human monoclonal antibody against IL-1β) at dose of 150 mg every 4 weeks induced a rapid remission of the disease activity and inflammatory markers. However, due to relapse of acute flares after three weeks from application, the escalation of dose to 300 mg every 4 weeks induced a complete remission of symptoms and significantly improved the quality of life. This is the first report of successful canakinumab administration in FMF patient in Central and Eastern Europe, a region with very low incidence of FMF (Tab. 1, Ref. 16).

Keywords: autoinflammation, monogenic periodic fever syndromes, familial Mediterranean fever, amyloidosis, colchicine-resistant disease, canakinumab
Published online: 09-Apr-2018
Year: 2018, Volume: 119, Issue: 4 Page From: 198, Page To: 200

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