Home Bratislava Medical Journal 2018 Bratislava Medical Journal Vol.119, No.4, p.201-204, 2018

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.119, No.4, p.201-204, 2018

Title: Structural aspects of Alzheimer’s disease immunotherapy targeted against amyloid-beta peptide
Author: O. Cehlar, R. Skrabana, V. Revajova, M. Novak

Abstract: Alzheimer’s disease is the most prominent neurodegenerative disease and has no efficient therapies available so far. Immunotherapy against amyloid-β (Aβ) peptide is one of the currently tested therapeutic approaches. Here we have reviewed the available structural knowledge about antibodies tested as passive anti-Aβ immunotherapy in clinical trials. The therapeutic anti-Aβ antibodies differ in their epitope specificity and in recognition and affinity to different Aβ species present in vivo (Tab. 1, Fig. 1, Ref. 17).

Keywords: Alzheimer’s disease, amyloid beta, immunotherapy, antibody-amyloid complex
Published online: 09-Apr-2018
Year: 2018, Volume: 119, Issue: 4 Page From: 201, Page To: 204

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