Bratislava Medical Journal Vol.119, No.4, p.245-248, 2018

Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.119, No.4, p.245-248, 2018
Title: Would Janus’ view on HDL be useful?
Author: M. Kasko, V. Kasko, S. Oravec

Abstract: Low-density lipoprotein cholesterol (LDL-C) is generally considered to be pro-atherogenic and high-density lipoprotein cholesterol (HDL-C) to be anti-atherogenic. The clinical approach to the diagnostics and treatment of clinical manifestations of atherosclerosis is the examination of the lipid spectrum. In routine clinical practice, the effects of the HDL class are measured only by determining the concentration of HDL cholesterol. It is questionable whether this clinical approach provides sufficient information to evaluate both the overall cardiovascular risk and the effect of hypolipidemic therapy. Recent studies revealed a shift from large to small HDL particles within the HDL family in the state of atherosclerotic cardiovascular diseases (CVD). This trend of lipoprotein constellation seems to be pathognomonic for dysfunctional lipoprotein profile under pathological state of the cardiovascular system. Thus, the diagnostic and therapeutic approach based on “good” cholesterol concept needs remedying (Fig. 1, Ref. 28).

Keywords: HDL, cholesterol, lipoproteins, atherosclerosis
	Published online: 09-Apr-2018
Year: 2018, Volume: 119, Issue: 4	Page From: 245, Page To: 248
doi:10.4149/BLL_2018_046
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