Home Acta Virologica 2018 Acta Virologica Vol.62, No.2, p.191-195, 2018

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.62, No.2, p.191-195, 2018

Title: Antiviral effect of a derivative of isonicotinic acid enisamium iodide (FAV00A) against influenza virus
Author: D. COCKING, J. CINATL, D. A. BOLTZ, X. PENG, W. JOHNSON, M. MUZZIO, O. SYARKEVYCH, G. KOSTYUK, A. GOY, L. MUELLER, V. I. MARGITICH

Abstract: With only a single class of antiviral drugs existing for treatment of influenza (neuraminidase inhibitors), the search for novel effective compounds is urgently needed. We evaluated a low molecular mass compound, enisamium iodide (FAV00A), against influenza virus infections in primary differentiated normal human bronchial epithelial (NHBE) cells, and in ferrets. FAV00A (500 µg/ml) markedly inhibited influenza virus replication and reduced viral M-gene expression in NHBE cells. Treatment of ferrets with FAV00A (200 mg/kg once daily for 7 days) initiated 24 h after inoculation with 105 TCID50 of influenza A/Wisconsin/67/2005 (H3N2) virus resulted in a significant decrease in virus titers in the upper respiratory tract. Our data show that FAV00A exhibits an antiviral effect against influenza virus in NHBE cells and provides some benefits in a ferret model. Thus, further

Keywords: antiviral agents; enisamium iodide; influenza virus; MDCK cells; NHBE cells; ferrets
Published online: 07-Jun-2018
Year: 2018, Volume: 62, Issue: 2 Page From: 191, Page To: 195
doi:10.4149/av_2018_211


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