Home Acta Virologica 2018 Acta Virologica Vol.62, No.2, p.220-225, 2018

Journal info

Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

Aims and Scope
Editorial Info

Abstracted and Indexed
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Acta Virologica Vol.62, No.2, p.220-225, 2018

Title: Kaempferol inhibited bovine herpesvirus 1 replication and LPS-induced inflammatory response
Author: L. ZHU, P. WANG, W. YUAN, G. ZHU

Abstract: Plant-derived flavonoids contain large amount of compounds with pharmacological effects. In this study, we showed the compound Kaempferol to have robust antiviral activity against bovine herpesvirus 1 (BoHV-1) replication in vitro. Kaempferol at a concentration of 100 μmol/l completely inhibited viral replication in MDBK cells. It mainly affects the viral replication at the post-entry stages. The inhibition of Akt signaling is a potential mechanism underlying the antiviral effect of Kaempferol. In addition, at a concentration of 25 and 50 μmol/l Kaempferol could significantly reduce the expression of inflammatory mediators such as tumor necrosis factor alpha (TNF-α), interleukin-8 (IL-8) and macrophage inflammatory protein 1 alpha (MIP-1α) in human promonocytic U937 cells-derived macrophages (dU937) in response to lipopolysaccharides (LPS) stimulation. Overall, our results indicated that Kaempferol provides a potent protection against BoHV-1 infection and LPS-induced inflammatory response.

Keywords: BoHV-1; inflammation; Kaempferol; cytokine
Published online: 07-Jun-2018
Year: 2018, Volume: 62, Issue: 2 Page From: 220, Page To: 225

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.