Home Acta Virologica 2018 Acta Virologica Vol.62, No.2, p.220-225, 2018

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.62, No.2, p.220-225, 2018

Title: Kaempferol inhibited bovine herpesvirus 1 replication and LPS-induced inflammatory response
Author: L. ZHU, P. WANG, W. YUAN, G. ZHU

Abstract: Plant-derived flavonoids contain large amount of compounds with pharmacological effects. In this study, we showed the compound Kaempferol to have robust antiviral activity against bovine herpesvirus 1 (BoHV-1) replication in vitro. Kaempferol at a concentration of 100 μmol/l completely inhibited viral replication in MDBK cells. It mainly affects the viral replication at the post-entry stages. The inhibition of Akt signaling is a potential mechanism underlying the antiviral effect of Kaempferol. In addition, at a concentration of 25 and 50 μmol/l Kaempferol could significantly reduce the expression of inflammatory mediators such as tumor necrosis factor alpha (TNF-α), interleukin-8 (IL-8) and macrophage inflammatory protein 1 alpha (MIP-1α) in human promonocytic U937 cells-derived macrophages (dU937) in response to lipopolysaccharides (LPS) stimulation. Overall, our results indicated that Kaempferol provides a potent protection against BoHV-1 infection and LPS-induced inflammatory response.

Keywords: BoHV-1; inflammation; Kaempferol; cytokine
Published online: 07-Jun-2018
Year: 2018, Volume: 62, Issue: 2 Page From: 220, Page To: 225
doi:10.4149/av_2018_206


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