Bratislava Medical Journal Vol.119, No.5, p.278-283, 2018

Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.119, No.5, p.278-283, 2018
Title: miRNA-489 as a biomarker in diagnosis and treatment of cervical cancer
Author: C. Juan, Q. Hua, Z. Ruping, W. Tingting

Abstract: miRNA-489 was shown to be a suppressor factor in many cancers, however, evidence on the effects and mechanism of miRNA-489 in progression of cervical cancer is limited. So we aimed to determine the function of miRNA-489 in cervical cancer proliferation and apoptosis in our present study. Interestingly, we found that miRNA-489 was significantly down-regulated in cervical cancer tissues. miRNA-489 overexpression inhibited the cell proliferation and improved the cell apoptosis of cervical cancer cells. Further, miRNA-489 over-expression suppressed the activation of PI3K and AKT, and stimulated P53 proteins expression. In conclusion, our results suggested that miRNA-489 may be considered as a biomarker in cervical cancer and had suppressed the cell proliferation and stimulated cell apoptosis via PI3K/AKT/P53 signaling pathway (Fig. 5, Ref. 26). Text in PDF www.elis.sk.

Keywords: miRNA-489, PI3K, AKT, P53, biomarker
	Published online: 09-May-2018
Year: 2018, Volume: 119, Issue: 5	Page From: 278, Page To: 283
doi:10.4149/BLL_2018_052
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