Home CONTACT Neoplasma 2018 Neoplasma Vol.65, No.3, p.326-330, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.3, p.326-330, 2018

Title: Clinical characteristics and treatments of patients with alpha-fetoprotein producing gastric carcinoma
Author: W. GONG, Y. SU, A. LIU, J. LIU, D. SUN, T. JIANG, J. XIANG, C. CHI, P. SUN

Abstract: Alpha-fetoprotein (AFP) is a well-known tumor marker of hepatic carcinoma and yolk sac tumor. Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare type of gastric cancer with high malignancy and poor prognosis, which makes it different from other types of gastric cancer. This rare gastric cancer patient subgroup is likely frequently misdiag- nosed which may be related to lack of knowledge about the disease. The purpose of this article is to summarize the mecha- nism of AFP positive gastric cancer, classification, biological behavior and treatment, in order to assist clinical practitioners to detect AFPGC earlier and treat it better. Previous studies have shown that AFPGC has a complex pathophysiology mecha- nism. AFPGC is aggressive and characterized by stronger proliferation, neovascularization, lymphatic invasion and distant metastasis. Furthermore, so far there has been no standard treatment for patients with AFPGC. Nevertheless, our present study summarizes some effective treatments based on previous research. In conclusion, the present study demonstrates the importance of detecting AFP routinely in serum and tissues in gastric cancer cases, which will greatly improve the diagnosis rate of AFPGC, and in regards to treatment, surgery, chemotherapy, targeted therapy and interventional treatment may have positive impacts on AFPGC treatment outcome. However, further study with a larger sample is required to confirm the reliability and validity of these methods.

Keywords: alpha-fetoprotein producing, gastric carcinoma, malignancy, prognosis, diagnosis, therapeutics
Published online: 16-May-2018
Year: 2018, Volume: 65, Issue: 3 Page From: 326, Page To: 330

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