Home Neoplasma 2018 Neoplasma Vol.65, No.3, p.415-424, 2018

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.65, No.3, p.415-424, 2018

Title: Novel insights into transcriptional dysregulation in colorectal cancer
Author: Y. FEODOROVA, D. TASHKOVA, I. KOEV, A. TODOROV, G. KOSTOV, K. SIMITCHIEV, V. BELOVEJDOV, R. DIMOV, V. SARAFIAN

Abstract: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Although CRC has been compre- hensively characterized at the molecular level, the tumor heterogeneity hinders the identification of reliable diagnostic, prognostic and predictive biomarkers. Molecular stratification of CRC is based on prevalent gene mutations and transcrip- tion profiles but its significance for clinical practice remains obscure. Indeed, activating mutations in the genes KRAS, NRAS, and BRAF are the only predictive biomarkers for anti-EGFR antibody therapy routinely tested in the clinic for advanced stages of CRC. Gene expression signatures are important for clarifying the molecular mechanisms of CRC development and progression, but only two such tests for predicting recurrence risk are commercially available. The aim of our study was to propose a diagnostic approach based on mutation and gene expression analysis that can be routinely applied in the clinic for defining the most appropriate treatment strategy for each patient. We used qPCR to determine the presence of KRAS mutations and measure the transcription levels of a panel of 26 genes in 24 CRC patients. Statistical analyses were applied to check for associations between clinicopathological and molecular parameters. Our results reveal novel data concerning CRC carcinogenesis: almost universal downregulation of EGFR; differential role of the pro-inflammatory cytokines TNF-α and IL-6; overexpression of the vitamin B12 transporter transcobalamin 1; tumor-suppressor function of SETD2, CA7, and GUCA2B. The practical application of these findings has yet to be clarified.

Keywords: CRC, gene expression, GUCA2B, KRAS
Published online: 16-May-2018
Year: 2018, Volume: 65, Issue: 3 Page From: 415, Page To: 424
doi:10.4149/neo_2018_170707N467
Price: 24.00 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.