Home Neoplasma 2018 Neoplasma Vol.65, No.3, p.431-435, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.3, p.431-435, 2018

Title: Human Cytomegalovirus (HCMV) infection was not correlated with overall survival in glioblastomas
Author: S. HAN, P. F. WANG, Y. X. XING, H. W. SONG, K. YAO, Z. X. LIN

Abstract: There are many arguments about the presence of HCMV (Human Cytomegalovirus) in malignant gliomas. This study was to investigate the presence and prognostic value of HCMV in glioblastomas. 68 patients including 64 primary glioblas- tomas and 4 secondary glioblastomas were involved in this study. Immunofluorescence was adopted for detecting glycopro- tein B (gB) and glycoprotein H (gH) of HCMV in glioblastoma tissues. Kaplan–Meier Analysis and Chi Square were used to evaluate patients’ survival and the association between HCMV infection and patients’ characteristics, respectively. We found that the presence rate of gB and gH in glioblastomas were 48.5% (33/68) and 42.6% (29/68), respectively. The co-occur- rence of gB and gH was 30.8%, and the presence rates of either gB or gH in glioblastomas were 60.3%. While IDH R132H mutations were significantly correlated with a better clinical outcome (p=0.006), the presence of neither gB (p=0.551) nor gH (p=0.871) had prognostic values. Furthermore, there was no significant association between the presence of HCMV and gliomas’ characteristics, neither with patients’ age, gender, KPS, IDH mutations nor PTEN loss. In conclusion, our results support the fact that HCMV is detected in glioblastomas. However, no predictive value of HCMV was observed, the treat- ment of glioblastomas targeting HCMV was needed to be reevaluated by studies again.

Keywords: glioblastoma, human cytomegalovirus, immunofluorescence, molecular pathology
Published online: 16-May-2018
Year: 2018, Volume: 65, Issue: 3 Page From: 431, Page To: 435
doi:10.4149/neo_2018_170124N59
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