Home Neoplasma 2018 Neoplasma Vol.65, No.3, p.436-440, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.3, p.436-440, 2018

Title: Hashimoto’s thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients
Author: H. MA, L. LI, K. LI, T. WANG, Y. ZHANG, C. ZHANG, Y. XU, X. WU, J. YU, H. WANG, B. XIANG, W. WANG, R. ZHANG

Abstract: Papillary thyroid carcinoma (PTC) is often combined with other types of thyroid disease, such as Hashimoto’s thyroiditis (HT), nodular goiter (NG), follicular adenoma (FA) and other types. However, the function of these diseases in PTC tumori- genesis and development is not well understood. In this research, 563 PTC patients were recruited and divided into two groups according to pathological diagnosis, namely simple PTC (PTC) and PTC combined with other thyroid diseases (PTC+). Clinicopathological characteristics and BRAFV600E mutation status were compared between PTC and PTC+. Our data showed that there was a statistically significant difference in gender (p=0.007), tumor diameter (5 mm, p=0.012; 1 cm, p=0.042), lymph node metastasis (p=0.000) and BRAFV600E mutation status (p=0.001) between PTC and PTC+. PTC+ patients have lower lymph node metastasis rate, even if PTC nodule diameter is larger than 5 mm (p=0.005) or ≥1 cm (p=0.049) or BRAFV600E is mutated (p=0.001). In conclusion, our study suggests that HT, NG and FA, are protective factors of PTC patients, and PTC+ patients have lower lymph node metastasis and BRAFV600E mutation rate compared with simple PTC   patients.

Keywords: papillary thyroid carcinoma, combined papillary thyroid carcinoma, protective effect, BRAF
Published online: 16-May-2018
Year: 2018, Volume: 65, Issue: 3 Page From: 436, Page To: 440
doi:10.4149/neo_2018_170428N317
Price: 12.00 €






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