Home Neoplasma 2018 Neoplasma Vol.65, No.3, p.469-476, 2018

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Founded: 1954
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ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.3, p.469-476, 2018

Title: FOXA1 and CK7 expression in esophageal squamous cell carcinoma and its prognostic significance
Author: Y. XU, W. WANG, L. LI, J. LIU, X. WU, J. YU, H. WANG, W. CUI, R. ZHANG

Abstract: Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors in human. Some ESCC cells express adenocarcinoma cell markers, such as Cytokeratin 7 (CK7), but the clinical significance of these cells in ESCC is unknown. Immunohistochemical analysis of CK7 and Fork head box protein A1 (FOXA1, an upstream regulator of CK7) was performed on 610 ESCC specimens using tissue microarray. In total, positive staining of CK7 was 59/594 (10%). CK7 expression was correlated with ESCC differentiation (p=0.006). The expression of CK7 is associated with poor overall survival (OS) of ESCC patients (p=0.0498). FOXA1 positive staining was 180/586 (31%). FOXA1 expression correlates with differentiation (p can be used as potential targets for ESCC therapy.

Keywords: FOXA1, CK7, esophageal squamous cell carcinoma, prognosis
Published online: 16-May-2018
Year: 2018, Volume: 65, Issue: 3 Page From: 469, Page To: 476
doi:10.4149/neo_2018_170529N384
Price: 19.20 €






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