Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.3, p.243–252, 2018

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.37, No.3, p.243–252, 2018

Title: Blood pressure management and progression of chronic kidney disease in a canine remnant kidney model
Author: Jun Gu Kang, Mi-yeon Yu, Hajeong Lee, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Seung Hee Yang

Abstract: The canine remnant kidney model is fundamental to understanding the relationship between
hypertension and chronic kidney disease (CKD). This study aimed to create a 1/16 remnant
kidney model and to determine whether blood pressure (BP) control affects the progression of
CKD. A group of dogs received BP treatment (group A) and another received BP treatment except
for the first 2 weeks (group B). The remnant kidney model was induced using a two-step subtotal
nephrectomy method; dogs received antihypertensive therapy. Systolic BP, blood urea nitrogen,
serum creatinine, urinary protein, and creatinine levels were measured weekly. Kidney tissues were
obtained at the conclusion of the study. Systolic BP was controlled to <160 mmHg in both groups
for 18 weeks, except for the first 2 weeks in group B. Proteinuria was elevated after renal ligation in
both groups, but gradually increased in group B and decreased in group A (p = 0.009). Blood urea
nitrogen (p = 0.014) and creatinine (p = 0.020) levels were higher in group B than in group A. More
histological damage was observed in group B than in group A. Induction of 1/16 nephrectomy successfully
established CKD. Control of BP may be important to prevent or control the progression
of CKD in dogs.

Keywords: Chronic kidney disease, Dog, Hypertension, Nephrectomy
Published online: 31-May-2018
Year: 2018, Volume: 37, Issue: 3 Page From: 243, Page To: 252

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