Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.37, No.3, p.243–252, 2018 |
||
Title: Blood pressure management and progression of chronic kidney disease in a canine remnant kidney model | ||
Author: Jun Gu Kang, Mi-yeon Yu, Hajeong Lee, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Seung Hee Yang | ||
Abstract: The canine remnant kidney model is fundamental to understanding the relationship between hypertension and chronic kidney disease (CKD). This study aimed to create a 1/16 remnant kidney model and to determine whether blood pressure (BP) control affects the progression of CKD. A group of dogs received BP treatment (group A) and another received BP treatment except for the first 2 weeks (group B). The remnant kidney model was induced using a two-step subtotal nephrectomy method; dogs received antihypertensive therapy. Systolic BP, blood urea nitrogen, serum creatinine, urinary protein, and creatinine levels were measured weekly. Kidney tissues were obtained at the conclusion of the study. Systolic BP was controlled to <160 mmHg in both groups for 18 weeks, except for the first 2 weeks in group B. Proteinuria was elevated after renal ligation in both groups, but gradually increased in group B and decreased in group A (p = 0.009). Blood urea nitrogen (p = 0.014) and creatinine (p = 0.020) levels were higher in group B than in group A. More histological damage was observed in group B than in group A. Induction of 1/16 nephrectomy successfully established CKD. Control of BP may be important to prevent or control the progression of CKD in dogs. |
||
Keywords: Chronic kidney disease, Dog, Hypertension, Nephrectomy | ||
Published online: 31-May-2018 | ||
Year: 2018, Volume: 37, Issue: 3 | Page From: 243, Page To: 252 | |
doi:10.4149/gpb_2017055 |
||
|
download file |
|