Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.3, p.275–283, 2018

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.37, No.3, p.275–283, 2018

Title: Analysis of Fos expression in the rat olfactory neurogenic region following single exposure to maternal separation during different neonatal stages
Author: Kamila Fabianová, Monika Závodská, Adam Raček, Andreas Angelidis, Marcela Martončíková, Enikő Račeková

Abstract: Accumulating evidence confirms that the exposure of neonatal rats to maternal separation
(MS) can significantly alter individual processes of postnatal neurogenesis in the olfactory
neurogenic region – the subventricular zone (SVZ) and the rostral migratory stream (RMS). To
establish the stressful influence of MS on postnatal neurogenesis we have investigated whether
altered olfactory environment caused by short-term MS induces expression of Fos protein in the
SVZ/RMS and in the olfactory cortical area – anterior olfactory nucleus (AON) of neonatal rats.
Pups were separated from mothers for 2 hours at the postnatal days 7, 14 and 21. Immunohistochemically
labeled Fos protein was assessed. Our results revealed that single exposure to MS is
a stressful event that selectively and in age-dependent manner stimulates cellular activity in the
SVZ and AON. A few Fos+ cells were found in the SVZ of P21 control animals and MS significantly
increased their number. This suggests that some SVZ cells are included in the circuitry, which is
activated by MS and that these cells have complete equipment for the Fos signal transduction. MS
significantly increased the number of Fos+ cells in the AON in all age stages examined suggesting
that its effect is mediated by olfaction.

Keywords: Fos protein, Maternal separation, Subventricular zone, Rostral migratory stream, Anterior olfactory nucleus
Published online: 31-May-2018
Year: 2018, Volume: 37, Issue: 3 Page From: 275, Page To: 283

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