Home FOR AUTHORS General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.3, p.285–297, 2018

Journal info


Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

Aims and Scope
Editorial Info
Abstracting and Indexing
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.37, No.3, p.285–297, 2018

Title: Comparison of training and detraining on redox state of rats: gender specific differences
Author: Jovana Bradic, Radica Dragojlovic Ruzicic, Jovana Jeremic, Anica Petkovic, Isidora Stojic, Tamara Nikolic, Vladimir Zivkovic, Ivan Srejovic, Dragan Radovanovic, Vladimir Lj. Jakovljevic

Abstract: Given the fact that oxidative stress response induced by training/detraining has still not
been clarified and may be influenced by gender, the aim of our investigation was to compare the
effects of swimming training and detraining on oxidative and antioxidative parameters in rats, with
a special focus on sex differences. Wistar albino rats (n = 64) were divided into 4 groups: control,
trained group, groups exposed to 2 and 4 weeks of detraining. Each group included two subgroups:
males and females. After sacrificing, hearts were isolated and retrogradely perfused according to
Langendorff technique. Levels of superoxide anion radical, hydrogen peroxide, nitrites and thiobarbituric
acid reactive substances were measured in plasma and coronary venous effluent, while
reduced glutathione, activities of superoxide dismutase and catalase were measured in erythrocytes.
Our results indicate that swimming training doesn’t promote oxidative damage, nor act protectively
within the heart. However, 2 and 4 weeks of detraining led to a partial lost in exercise-induced adaptation.
It seems that moderate-intensity physical exercise of sufficient duration leads to beneficial
adaptations, which may be partially lost during detraining period. Positive antioxidative effects of
training remained longer in males. Findings of present study may help in elucidation of training and
detraining effects on modulation of redox homeostasis, especially from aspect of gender differences.

Keywords:
Published online: 31-May-2018
Year: 2018, Volume: 37, Issue: 3 Page From: 285, Page To: 297
doi:10.4149/gpb_2017053


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.