Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.3, p.309–317, 2018

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.37, No.3, p.309–317, 2018

Title: Exercise training increased gene expression of LDL-R and PCSK9 in intestine: link to transintestinal cholesterol excretion
Author: Zahra Farahnak, Natalie Chapados, Jean-Marc Lavoie

Abstract: Transintestinal cholesterol excretion (TICE) is known as an alternate non-biliary route
of cholesterol excretion from the body. The aim of this study was to determine whether exercise
training has effects on intestinal membrane receptors involved in TICE in intact and ovariectomized
(Ovx) rats. Sprague-Dawley rats were first divided into 4 groups: Sham operated and Ovx rats fed
a standard diet (Sham-SD; Ovx-SD), or a high cholesterol diet (Sham-Chol; Ovx-Chol). These 4
groups were subsequently subdivided into either sedentary or voluntary wheel running groups for
6 weeks. The cholesterol diet resulted in increased hepatic cholesterol accumulation (p < 0.001) in
both Sham and Ovx rats. Exercise training increased (p < 0.01) transcripts of intestinal low density
lipoprotein receptor (LDL-R) and proprotein convertase subtilisin/kexin type 9 (PCSK9), which
are involved in trans-intestinal cholesterol uptake from circulation, in both Sham and Ovx rats
compared to rats remaining sedentary in all diet conditions. The up-regulation of intestinal gene
expression of LDL-R and PCSK9 following voluntary wheel running in intact and Ovx rats suggests
that exercise training may contribute to elimination of cholesterol through the TICE pathway.

Keywords: Intestinal cholesterol disposal, LDL-receptor, Liver cholesterol
Published online: 31-May-2018
Year: 2018, Volume: 37, Issue: 3 Page From: 309, Page To: 317

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