Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.3, p.337–343, 2018

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.37, No.3, p.337–343, 2018

Title: Antitussive activity of alcoxyphenyl carbamic acid analogues
Author: Jana Jurecekova, Gabriela Nosalova, Ludovit Jurecek, Jozef Csollei, Veronika Sivova, Slavomir Nosal

Abstract: In this study we report pharmacological evaluation of four newly synthetized analogues
of alcoxyphenyl carbamic acid, structurally related to butamirate citrate that is frequently used as
cough suppressing drug, and marked as ATK 231, ATK 241, ATK 251 and ATK 261. These agents
with various modifications of the molecular structure have been tested for antitussive activity in
cough induced by inhalation of aerosol of citric acid (0.3 M) over 3 minutes using conscious guinea
pigs. Results revealed significant cough suppressing activity without significant influence on specific
airways resistances in all tested substances. ATK 231 and ATK241 showed significantly higher total
antitussive activities when compared to both codeine phosphate and butamirate citrate, while ATK
251 only comparing to butamirate citrate. We did not observe any notable adverse effects and these
compounds could thus potentially represent promising new non-narcotic antitussives suitable for
further studies.

Keywords: Cough, Citric acid, Guinea pigs, Airways resistance, Antitussive activity
Published online: 31-May-2018
Year: 2018, Volume: 37, Issue: 3 Page From: 337, Page To: 343

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