Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.3, p.345–352, 2018

Journal info


Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

Aims and Scope
Editorial Info
Abstracting and Indexing
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.37, No.3, p.345–352, 2018

Title: Acute sleep deprivation induces cardioprotection against ischemia/ reperfusion injury through reducing inflammatory responses: the role of central GABA-A receptors
Author: Hoda Parsa, Mahdieh Faghihi, Gholam A. Kardar, Alireza Imani

Abstract: Sleep is considered as a physiological regulator in the body. Gamma-aminobutyric acid
(GABA) is a neurotransmitter that modulates sleep and affects cardiac functions. We evaluated effects
of acute sleep deprivation (SD) on cardiac hemodynamic parameters, expression of pro-inflammatory
cytokines, and Heat shock protein (Hsp70), serum level of lactate dehydrogenase (LDH) and prooxidant/
antioxidant balance (PAB). Male Wistar rats were bilaterally cannulated in the central nucleus
of amygdala (CeA) and saline or bicuculline was injected 24 hours prior to induction of 30 minute
ischemia following 120 minute reperfusion. Forty-eight animals were randomly divided into four
groups: Control (CONT), bicuculline (BIC), acute SD and bicuculline + acute sleep deprivation
(BIC+SD). Animals in SD and BIC+SD groups were put in an aquarium for inducing sleep deprivation.
SD attenuated LDH, pro-inflammatory cytokines and PAB; improved cardiac hemodynamic
parameters and increased Hsp70 in non-infarcted area as compared to CONT. Administration of
bicuculline increased LDH, pro-inflammatory cytokines and PAB, reduced cardiac hemodynamic
parameters and Hsp70 as compared to CONT. Furthermore, bicuculline administration prior to acute
sleep induction decreased SD effects on LDH, PAB, Hsp70, cardiac hemodynamic parameters and
pro-inflammatory cytokines. Induction of SD prior to ischemia/reperfusion induces cardioprotection
through suppressing inflammatory responses.

Keywords: Acute sleep deprivation, Cardioprotection, GABA, Inflammatory responses, Lactate dehydrogenase
Published online: 31-May-2018
Year: 2018, Volume: 37, Issue: 3 Page From: 345, Page To: 352
doi:10.4149/gpb_2017049
Price: 16.00 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.