Home General Physiology and Biophysics 2018 General Physiology and Biophysics Vol.37, No.3, p.353–357, 2018

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.37, No.3, p.353–357, 2018

Title: Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1
Author: Zuzana Kocibalova, Martina Guzyova, Denisa Imrichova, Zdena Sulova, Albert Breier

Abstract: Finding new markers with appropriate prognostic levels for the differential diagnosis of
neoplastic diseases represents an important issue for biomedical research. Recently, latrophilin-1
(LPHN1) was reported to be expressed in human monocytic leukemia cell lines and in primary
human acute myeloid leukemia (AML) cells. However, this expression was found to be absent in
healthy leukocytes. LPHN1 was therefore considered a novel biomarker of human AML. In previous
papers, we established two P-gp-positive variants (SKM-1/VCR and MOLM-13/VCR) of AML
cell lines derived from parental human AML cells SKM-1 and MOLM-13 by selection with VCR.
The present paper addresses the measurement of LPHN1 expression in SKM-1 and MOLM-13 cells
and their P-gp-positive variants. Both parental AML lines were positive for LPHN1 expression at
the mRNA and protein levels. However, the expression of LPHN1 at both the mRNA and protein
levels was reduced in both P-gp-positive SKM-1/VCR and MOLM-13/VCR variants of AML cells.
Interestingly, we observed an elevation of the latrophilin-3 transcript in P-gp-positive variants of
AML cell lines. The combined results suggest that alterations in latrophilin expression occur in AML
cells expressing P-gp.

Keywords: AML, AML cell lines, P-glycoprotein, Latrophilins, Vincristine
Published online: 31-May-2018
Year: 2018, Volume: 37, Issue: 3 Page From: 353, Page To: 357

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