Home Acta Virologica 2018 Acta Virologica Vol.62, No.2, p.208-213, 2018

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.62, No.2, p.208-213, 2018

Title: Evidence of hepatitis A virus infection in the patients with acute encephalitis syndrome in Gorakhpur region, North India
Author: M. S. JOSHI, B. V. TANDALE, M. M. GORE, S. BHALLA, Y. K. GURAV, G. N. SAPKAL, K. P. KUSHWAHA, A. C. MISHRA, S. D. CHITAMBAR

Abstract: The etiological agent remained unidentified in a large number of patients hospitalized for acute encephalitis syndrome (AES) in 2008–2009 in Uttar Pradesh and Bihar, north India. All patients were found to present with fever and altered sensorium, while 28%, 19% and 13% showed hepatomegaly, splenomegaly and meningeal signs, respectively. Involvement mostly of children with abnormal hepatic features prompted us to undertake an exploratory study on viral hepatitis A to determine its association, if any, with hepatic derangements. AES patients (n = 2515) and healthy children (n = 167) were investigated for the presence of serum anti-hepatitis A virus (anti-HAV) IgM and anti-Japanese encephalitis (anti-JE) virus IgM by ELISA. Cerebrospinal fluids (CSFs, n = 595) and rectal swabs (n = 182) were examined for anti-HAV IgM and/or HAV RNA. Anti-HAV IgM was detected in the sera of 14.6% patients as against 6.6% of healthy children (p = 0.0042). Anti-JE virus IgM positivity was

Keywords: acute encephalitis syndrome; cerebrospinal fluid; hepatitis A virus; anti-HAV IgM; non-Japanese encephalitis
Published online: 07-Jun-2018
Year: 2018, Volume: 62, Issue: 2 Page From: 208, Page To: 213
doi:10.4149/av_2018_215


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