Home Neoplasma 2018 Neoplasma Vol.65, No.5, p.807-814, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.5, p.807-814, 2018

Title: Expression of autophagy genes in acute myeloid leukemia: associations with clinical characteristics and prognosis
Author: P.Q. LIANG, M. MIAO, R. HU, Z.G. LIU, H.N. JIANG, C. LI, S.Y. MA

Abstract: The relationships between autophagy-associated gene expression and clinical characteristics and prognosis in acute myeloid leukemia (AML) have not been well revealed. We examined mRNA expression of Bcl-2, p62, Beclin 1, VPS34, Rubicon, ALFY, UVRAG, ULK1, LC3 and NBR1 in 20 AML cases and 10 benign hematological cases by real-time PCR. Clinical information, treatment responses and outcomes of the AML patients were collected. Beclin 1, LC3, UVRAG, Rubicon and NBR1 were downregulated in AML patients compared with control group (p

Keywords: acute myeloid leukemia; autophagy; clinical outcome
Published online: 24-Sep-2018
Year: 2018, Volume: 65, Issue: 5 Page From: 807, Page To: 814

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